Background: Psychiatric emergencies are acute disturbances in behavior, thought, or mood that require immediate intervention to prevent harm to the individual or others. Caregivers of persons with mental disorders play a vital role in recognizing early warning signs and initiating timely management during such emergencies.

Aims: To assess the effectiveness of a Structured Teaching Programme (STP) on knowledge regarding selected psychiatric emergencies among caregivers of patients with mental disorders in a mental health institution, Odisha.

Methods: A quantitative research approach with a pre-experimental one-group pretest–posttest design was adopted. The study was conducted among 50 caregivers selected through non-probability convenient sampling. Data were collected using a self-structured knowledge questionnaire consisting of 25 multiple-choice questions. A Structured Teaching Programme on psychiatric emergencies was administered after the pretest, and posttest was conducted after seven days.

Results: The mean pretest knowledge score was 12.40 (SD = 3.10), which increased to 18.90 (SD = 2.80) in the posttest. The calculated paired‘t’ value (t = 18.72, p < 0.001) indicated a statistically significant improvement in knowledge. Significant associations were found between posttest knowledge scores and selected socio-demographic variables such as age, educational status, and relationship with patient, duration of caregiving, and previous exposure to information.